Fabrication and properties of L-arginine-doped PCL electrospun composite scaffolds

摘要

The article describes fabrication and properties of composite fibrousscaffolds obtained by electrospinning of the solution ofpoly({\epsilon}-caprolactone) and arginine in common solvent. The influence ofarginine content on structure, mechanical, surface and biological properties ofthe scaffolds was investigated. It was found that with an increase of arginineconcentration diameter of the scaffold fibers was reduced, which wasaccompanied by an increase of scaffold strength and Young modulus. It wasdemonstrated that porosity and water contact angle of the scaffold areindependent from arginine content. The best cell adhesion and viability wasshown on scaffolds with arginine concentration from 0.5 to 1 % wt.